trajectories

In this series of blogposts, we look at some models of clinical state. The motivation is to document exploratory work with a colleague (Nick Meyer, who runs the SleepSight study) as we try and apply some theoretical ideas – for example (Nelson et al.

The motivation for looking at this topic was primarily my naivety and getting counter-intuitive results when I was looking at serial measures of response to treatment. In particular, I wanted to use outcome measures based on published conventions in the literature for threshold response (the problems with this approach are a topic for another day).